Project Overview
Location
Basel, Switzerland
Capacity
500 L/h (0.5 m³/h)
Water Quality
High-Purity Purified Water (Resistivity ≥15 MΩ⋅cm )
System Type
Double-Stage RO + EDI + Sanitary Loop
The Challenge
A leading biopharmaceutical and vaccine development enterprise in Basel, Switzerland, required a compact, highly reliable pure water system to supply daily laboratory analysis, buffer and media preparation, and critical equipment rinsing.
- Zero Microbial & Endotoxin Tolerance: Biopharmaceutical applications demand strict compliance with international pharmacopeia standards (USP/EP), requiring complete elimination of bacterial endotoxins, total organic carbon (TOC), and ionic contaminants.
- Continuous High Resistivity Requirement: Unlike standard industrial RO, downstream chemical synthesis and biological formulations required a stable, chemical-free polishing loop to maintain a consistent resistivity of 15 MΩ⋅cm.
- Sanitary Compliance & Validation Support: All wetted components required premium stainless steel (SS316L) with sanitary electropolished finishes, zero dead-leg piping design, and full Clean-in-Place (CIP) / Sterilization-in-Place (SIP) capabilities.
Our Custom Engineering Solution
We engineered a fully integrated, modular 500 L/h double-stage RO combined with an advanced EDI (Electrodeionization) system tailored for pharmaceutical-grade production:
Pre-treatment & Sanitization Stage
Features multi-media filtration, activated carbon, and softening modules paired with automatic thermal or UV sanitization to control microbial growth from the raw water feed.
Double-Stage RO Core
The first pass reduces bulk mineral content, while the second pass further lowers ionic load, ensuring an exceptionally stable, low-conductivity feed for the downstream polishing module.
Sanitization
Integrated UV Sterilizer and 0.22-micron ozone-resistant membrane filtration.
EDI Polishing & Sanitary Loop
Utilizes a continuous electrodeionization (EDI) module to remove residual ions without chemical regeneration, followed by UV oxidation, sub-micron ultrafiltration, and a sanitary distribution loop to guarantee sterile, high-resistivity water delivery.
Project Results & Benefits
Following successful installation, FAT/SAT validation, and commissioning, the 500 L/h double-stage RO+EDI system delivered exceptional performance, consistently producing purified water with resistivity exceeding 
and total organic carbon (TOC) well below pharmaceutical regulatory limits. The deployment of sanitary SS316L loop piping and automated heat-sanitization cycles ensured complete microbiological control, satisfying all European Pharmacopeia (EP) validation protocols and providing a stable, reliable foundation for the facility’s biotech research and manufacturing operations.
Technical Specifications
| APPLICABLE WATER SOURCE | Urban tap water, groundwater, raimwater, river water, lake water. |
| SYSTEM DESIGN CAPACITY | 500L/h(continuous pure water output) |
| TECHNICAL INDICATORS | System Desalination Rate≥99.5%；Recovery Rate≥65%-70% |
| WATER QUALITY | Resistivity ≥15 MΩ⋅cm (25℃), Conductivity ≤0.1 μS/cm , TOC <50 ppb |
| POWER SUPPLY | AC 400V/50HZ 3P (Complying with CE and pharmaceutical electrical safety codes) |
| MATERIAL&CONSTRUCTION | Sanitary Grade SS316L for all pure water contact surfaces, Ra  electropolished |
| PROCESS FLOW LINE | Feedwater  Softener / Pre-treatment Double-Stage RO Host EDI Polishing Module UV Sterilizer Ultrafiltration Sanitary Storage & Distribution Loop |